Syntheses of 4 and 5‐alkylsulfonylimidazoles | Zendy

Shafiee A. | Zendy; Akbarzadeh T. | Zendy; Foroumadi A. | Zendy; Hadizadeh F. | Zendy

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Syntheses of 4 and 5‐alkylsulfonylimidazoles

Author(s) -

Shafiee A.,

Akbarzadeh T.,

Foroumadi A.,

Hadizadeh F.

Publication year - 1998

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570350126

Subject(s) - chemistry , alkylation , imidazole , halide , alkyl , sodium salt , sodium , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis , inorganic chemistry

A series of isomeric 4 and 5‐alkylsulfonyl, alkylsulfinylimidazoles 9,10 were prepared by two general methods. Chlorosulfonation of imidazole afforded 4(5)‐chlorosulfonylimidazoles 2, 4, 5 . The chlorosulfonyl derivatives were reduced, alkylated and oxidized to give 9 and 10 . In the second method 2, 4, 5 were converted to sodium sulfinate 8 and reacted with alkyl halides to afford the title compound 9 .

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