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Syntheses of 4 and 5‐alkylsulfonylimidazoles
Author(s) -
Shafiee A.,
Akbarzadeh T.,
Foroumadi A.,
Hadizadeh F.
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350126
Subject(s) - chemistry , alkylation , imidazole , halide , alkyl , sodium salt , sodium , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis , inorganic chemistry
A series of isomeric 4 and 5‐alkylsulfonyl, alkylsulfinylimidazoles 9,10 were prepared by two general methods. Chlorosulfonation of imidazole afforded 4(5)‐chlorosulfonylimidazoles 2, 4, 5 . The chlorosulfonyl derivatives were reduced, alkylated and oxidized to give 9 and 10 . In the second method 2, 4, 5 were converted to sodium sulfinate 8 and reacted with alkyl halides to afford the title compound 9 .