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Synthesis of pyrazolo[1,5‐ a ]pyrimidines in the reaction of 5‐amino‐3‐arylpyrazoles with methoxymethylene meldrum's acid derivatives and thermolysis of their pyrazolylaminomethylene derivatives
Author(s) -
Quiroga Jairo,
Hormaza Angelina,
Insuasty Braulio,
Saitz Claudio,
Cañete Alvaro,
Jullian Carolina
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350112
Subject(s) - chemistry , meldrum's acid , nitrobenzene , thermal decomposition , organic chemistry , catalysis
A series of pyrazolo[1,5‐ a ]pyrimidin‐3‐ones 3 was prepared from Meldrum's acid and 5‐amino‐3‐arylpyrazoles 1 by cyclization in nitrobenzene of the corresponding 5‐pyrazolylaminomethylene Meldrum's acid derivatives 2 . The structure of pyrazolo[1,5‐ a ]pyrimidin‐3‐ones and their precursors were determined by nmr measurements.