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Synthesis of purinobenzothiazine and pyridothiazinopurine derivatives. Two new heterocyclic ring systems
Author(s) -
Settimo Antonio Da,
Marini Anna Maria,
Primofiore Giampaolo,
Settimo Federico Da,
Bertini Daniele
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350111
Subject(s) - chemistry , benzothiazine , ring (chemistry) , ullmann reaction , benzoic acid , bicyclic molecule , stereochemistry , medicinal chemistry , combinatorial chemistry , purine , organic chemistry , catalysis , enzyme
The synthesis of derivatives of two new heterocyclic systems, purino[8,7‐ b ][1,3]benzothiazine and pyrido[3′,2′:5,6][1,3]thiazino[3,2‐ f ]purine, was effected by the Ullmann reaction between 8‐mercaptotheophylline or 8‐bromotheophylline with the appriopriately substituted benzoic or nicotinic acid, respectively. The 8,8′‐dithiobistheophylline is also reported.