Synthesis of 4‐(pyrazol‐5‐yl)‐1,2,4‐triazole‐3‐thiones | Zendy

Vicentini Chiara B. | Zendy; Manfrini Maurizio | Zendy; Veronese Augusto C. | Zendy; Guarneri Mario | Zendy

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Synthesis of 4‐(pyrazol‐5‐yl)‐1,2,4‐triazole‐3‐thiones

Author(s) -

Vicentini Chiara B.,

Manfrini Maurizio,

Veronese Augusto C.,

Guarneri Mario

Publication year - 1998

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570350106

Subject(s) - chemistry , acetic anhydride , formic acid , acetic acid , 1,2,4 triazole , triazole , organic chemistry , condensation , medicinal chemistry , catalysis , physics , thermodynamics

Condensation of pyrazolyl isothiocyanates 2 with N ‐substituted hydrazines provided the 2‐methyl/phenyl‐4‐(pyrazol‐5‐yl)thiosemicarbazides 3 . Cyclization of 3 with formic acid‐acetic anhydride or with triethyl orthoacetate‐acetic anhydride provided 4‐(pyrazol‐5‐yl)‐l,2,4‐triazole‐3‐thiones 4a‐f and 5‐methyl‐4‐(pyrazol‐5‐yl)‐1,2,4‐triazole‐3‐thiones 4g‐I respectively.

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