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Synthesis of 4‐(pyrazol‐5‐yl)‐1,2,4‐triazole‐3‐thiones
Author(s) -
Vicentini Chiara B.,
Manfrini Maurizio,
Veronese Augusto C.,
Guarneri Mario
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350106
Subject(s) - chemistry , acetic anhydride , formic acid , acetic acid , 1,2,4 triazole , triazole , organic chemistry , condensation , medicinal chemistry , catalysis , physics , thermodynamics
Condensation of pyrazolyl isothiocyanates 2 with N ‐substituted hydrazines provided the 2‐methyl/phenyl‐4‐(pyrazol‐5‐yl)thiosemicarbazides 3 . Cyclization of 3 with formic acid‐acetic anhydride or with triethyl orthoacetate‐acetic anhydride provided 4‐(pyrazol‐5‐yl)‐l,2,4‐triazole‐3‐thiones 4a‐f and 5‐methyl‐4‐(pyrazol‐5‐yl)‐1,2,4‐triazole‐3‐thiones 4g‐I respectively.