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Syntheses of new pyridonecarboxylic acid derivatives containing 1‐ or 2‐naphthyl substituents at n‐1 and their anti‐hiv‐rt activities
Author(s) -
Oh YoonSeok,
Cho SungHye
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350104
Subject(s) - chemistry , human immunodeficiency virus (hiv) , in vitro , stereochemistry , organic chemistry , biochemistry , virology , biology
Abstract A series of new pyridonecarboxylic acid derivatives containing 1‐ or 2‐naphthyl substituents at N‐1 were synthesized and their in vitro anti‐HIV‐RT activities were evaluated. Several compounds in this series showed better activity than Atevirdine.