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Diethyl ethoxymethylenemalonate in triheterocycles: A new synthesis of pyrido[3,2‐ e ]pyrimido[1,2‐ c ]pyrimidines
Author(s) -
Dave Chaitanya G.,
Shukla Manish C.
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340627
Subject(s) - chemistry , hydrolysis , alkaline hydrolysis , pyrimidine , stereochemistry , medicinal chemistry , organic chemistry
Diethyl ethoxymethylenemalonate was used for the novel synthesis of the triheterocyclic 3‐carbethoxy‐9,ll‐disubstituted‐4‐oxo‐4 H ‐pyrido[3,2‐ e ]pyrimido[1,2‐ c ]pyrimidines from 4‐aminopyrido[2,3‐ d ]pyrim‐idines via thermal cyclization of the intermediate ethyl 2‐carbethoxy‐3‐[5,7‐disubstituted‐4‐amino‐pyrido[2,3‐ d ]pyrimidin‐4‐yl]acrylates. The alkaline hydrolysis of 3‐carbethoxy‐4‐oxo‐4 H ‐pyrido[3,2‐ e ]‐pyrimido[1,2‐ c ]pyrimidines was performed to give corresponding acid derivatives.