Premium
The synthesis and transformation of ethyl 2‐(2‐acetyl‐2‐benzoyl‐1‐ethenyl)amino‐3‐dimethylaminopropenoate. A new synthesis of 2,3,4‐trisubstituted pyrroles
Author(s) -
Malešič Mateja,
Krbavčič Aleš,
Golobič Amalija,
Golič Ljubo,
Stanovnik Branko
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340619
Subject(s) - chemistry , transformation (genetics) , medicinal chemistry , organic chemistry , stereochemistry , biochemistry , gene
The synthesis of ethyl 2‐(2‐acetyl‐2‐benzoyl‐1‐ethenyl)amino‐3‐dimethylarninopropenoate ( 4 ) from benzoylacetone ( 1 ) via 3‐dimethylarninomethylenebenzoylacetone ( 2 ) and ethyl N ‐(2‐acetyl‐2‐benzoyl‐1‐ethenyl)glycinate ( 3 ) and its transformation into 4‐benzoyl‐2‐ethoxycarbonyl‐3‐methylpyrrole ( 9 ) is described. Cyclization of 4 into 9 represents a new synthesis of polysubstituted pyrroles.