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Researches on pyridodiazepines. Behavior of 7,8,9,10‐tetrahydro‐5‐methylcyclopenta[e]pyrido[3,2‐ b ][1,4]‐diazepin‐6(5 H )‐one with chloroacetyl chloride
Author(s) -
Boido Alessandro,
Savelli Francesco,
Sancassan Fernando
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340544
Subject(s) - chloroacetyl chloride , chemistry , conjugated system , ring (chemistry) , pyridine , medicinal chemistry , chloride , cycloaddition , closure (psychology) , double bond , condensation , organic chemistry , catalysis , physics , economics , market economy , thermodynamics , polymer
Following a previous experiment, an original heteropolycyclic structure 4 was obtained by a reaction of chloroacetyl chloride with compound 3 bearing a conjugated double bond system. The condensation develops with an initial NH‐chloroacetylation and ring closure by quaternarization of the pyridine nitrogen. This is achieved through an 1,4 ‐cycloaddition of chloroketene to make a pyranone ring.