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On triazoles XXXVIII . The reaction of isomeric 5‐amino‐3‐morpholino‐1 H ‐1,2,4‐triazolylcarbothiohydrazides with ortho esters
Author(s) -
Reiter József,
Barkóczy József
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340531
Subject(s) - chemistry , morpholino , ring (chemistry) , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , zebrafish , gene
The reaction of isomeric differently methylated 5‐amino‐3‐morpholino‐1 H ‐1,2,4‐triazolylcarbo‐thiohydrazides with ortho esters were studied. Except of the case of triethyl orthoacetate instead of the expected [1,2,4]triazolo[1,5‐ d ][1,2,4,6]tetrazepin‐5(7 H )‐thione ( 6 ) derivatives different rearranged products such as 7, 8, 21, 23, 25 , and 27 were obtained, derivatives 23 and 27 representing a novel ring system. Possible explanations were given for the formation of the rearranged products.