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Synthesis of 2,3‐dihydropyrido‐ and 2,3‐dihydropyrimido‐[1,4]diazepines from triaminopyridine and triaminopyrimidine
Author(s) -
Insuasty Braulio,
Perez Alfredo,
Valencia John,
Quiroga Jairo
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340528
Subject(s) - chemistry , diazepine , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , ring (chemistry)
The reaction of 2,3,6‐triaminopyridine 1 and 4,5,6‐triaminopyrimidine 2 with one equivalent of the chal‐cones 3, in acetic acid, leads to the formation of the 8‐amino‐2,3‐dihydro‐1 H ‐pyrido[2,3‐ b ][1,4]diazepine and 6‐amino‐2,3‐dihydro‐1 H ‐pyrimido[4,5‐ b ][1,4]diazepine derivatives 4 and 5 . The products were characterized by NMR techniques such as 13 C, 1 H, and DEPT including selective 13 C{ 1 H} decoupling experiments.