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Synthesis of new indoyl‐1,3,4‐oxadiazole and oxadiazine derivatives. Potential monoamine oxidase inhibitor activity
Author(s) -
Pérez Silvia,
Lasheras Berta,
Oset Carmen,
Monge Antonio
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340523
Subject(s) - chemistry , oxadiazole , monoamine oxidase inhibitor , monoamine oxidase , pharmacology , stereochemistry , monoamine neurotransmitter , combinatorial chemistry , biochemistry , enzyme , organic chemistry , serotonin , receptor , medicine
New indolyl‐1,3,4‐oxadiazole and oxadiazine derivatives were prepared as reversible monoamine oxidase inhibitors. The compound 5‐(3‐methylindolyl)‐1,3,4‐oxadiazol‐2(3 H )one was shown to be a good monoamine oxidase B inhibitor.
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