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An expeditious procedure for the synthesis of purines from aminoimidazolecarbaldehydes
Author(s) -
Perandones Francisco,
Soto José L.
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340514
Subject(s) - chemistry , purine metabolism , formamide , pyrimidine , purine , ring (chemistry) , organic chemistry , combinatorial chemistry , stereochemistry , enzyme
Reactions of 4‐amino‐1,2‐dimethylimidazole‐5‐carbaldehyde ( 1 ) and 5‐amino‐1‐methylimidazole‐4‐car‐baldehydes 3 with nitriles, in the presence of dry hydrogen chloride afforded to the formation of purine derivatives. This constitutes a facile and versatile one‐pot synthesis of purines. The use of formamide instead of nitriles leads to the respective purines without substituents on the pyrimidine ring, 2d and 4e,f .
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