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Synthesis of 1,2,3‐triarylpyrroles from 1‐benzylbenzotriazoles via [1 + 2 + 2] annulation
Author(s) -
Katritzky Alan R.,
Wang Zouquan,
Li Jianqing,
Levell Julian R.
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340448
Subject(s) - chemistry , annulation , acetal , alkylation , formic acid , ethanol , alcohol , organic chemistry , medicinal chemistry , combinatorial chemistry , catalysis
Abstract 1,2,3‐Triarylpyrroles 7 have been synthesized by sequential lithiation and alkylation of 1‐benzylbenzo‐triazoles 1 with 2‐bromoacetaldehyde diethyl acetal (2) and N ‐benzylideneaniline (4), followed by treatment with formic acid in ethanol.