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Palladium‐catalyzed synthesis of 3‐(alkylamino)isoindolin‐1‐ones by carbonylative cyclization of 2‐bromobenzaldehyde with primary amines
Author(s) -
Cho Chan Sik,
Jiang Li Hong,
Lee Dong Yub,
Shim Sang Chul,
Lee Hyung Soo,
Cho SungDong
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340446
Subject(s) - chemistry , triethylamine , palladium , triphenylphosphine , primary (astronomy) , carbon monoxide , catalysis , medicinal chemistry , organic chemistry , chloride , polymer chemistry , physics , astronomy
2‐Bromobenzaldehyde reacts with an excess of primary amines under a carbon monoxide in the presence of a catalytic amount of bis(triphenylphosphine)palladium(II) chloride together with triethylamine to give the corresponding 3‐(alkylamino)isoindolin‐1‐ones in good yields.