Premium
Synthesis and reactions of 1‐(2‐oxopropyl)pyridazin‐6‐ones
Author(s) -
Choi WooYong,
Cho SuDong,
Kim SungKyu,
Yoon YongJin
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340436
Subject(s) - chemistry , nucleophile , acetic acid , nitro , zinc , ammonium chloride , organic chemistry , chloride , ammonium , medicinal chemistry , catalysis , alkyl
Oxopropylation of 4,5‐dihalopyridazin‐6‐ones with chloroacetone afforded the corresponding 1‐(2‐oxo‐propyl) derivatives. Reaction of title compound with nucleophiles such as amines, alkoxides were investigated. In addition, selective reduction of 3‐nitro‐1‐(2‐oxopropyl)pyridazin‐6‐ones with iron/ammonium chloride in two phase solutions or zinc in acetic acid gave the corresponding 3‐amino or 3‐hydroxyimino derivatives.