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Synthetic studies toward phenoxan analogs
Author(s) -
Zhang Xiaowei,
Hinkle Becky,
Ballantyne Lisa,
Gonzales Sam,
Peña Michael R.
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340356
Subject(s) - chemistry , oxazole , pyran , combinatorial chemistry , total synthesis , stereochemistry , organic chemistry
We developed two reactions needed for a total synthesis of phenoxan, a naturally occurring compound with anti‐HIV activity. In this Note, we further examined these two issues: metallation of a 2‐methyl‐oxazole and formation of a pyran‐4‐one. We employed these methods for the preparation of a phenoxan analog.