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Thermal reactions of 2‐(2‐oxo‐3‐nitro‐4‐quinolinyl)malonates
Author(s) -
Täubl A. Elisabeth,
Stadlbauer Wolfgang
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340343
Subject(s) - chemistry , nitro , thermal decomposition , substituent , differential scanning calorimetry , medicinal chemistry , yield (engineering) , organic chemistry , alkyl , thermodynamics , physics
Depending on the ester substituent, diethyl 2‐(3‐nitro‐2‐oxo‐4‐quinolinyl)malonates 2 give upon thermolysis ethyl 2‐(3‐nitro‐2‐oxo‐4‐quinolinyl)acetates 4, whereas dimethyl 2‐(3‐nitro‐2‐oxo‐4‐quinolinyl)‐malonates 3 cyclize to give 1‐methoxycarbonylisoxazolo[3,4‐ c ]quinolin‐4(5 H )‐ones 5. The necessary reaction conditions can be obtained easily with the help of differential scanning calorimetry.