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Synthesis and S ‐methylation of 2‐thioxopyrido[3′,2′:4,5]thieno[3,2‐ d ]‐pyrimidin‐4(3 H )‐ones with and without a phase transfer catalyst
Author(s) -
Dave Chaitanya G.,
Shah A. B.,
Shah H. C.
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340335
Subject(s) - chemistry , medicinal chemistry , phase (matter) , methylation , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , gene
A number of 2‐thioxopyrido[3′,2′:4,5]thieno[3,2‐ H ]pyrimdin‐4(3 H ‐ones (5) have been synthesized by cyclocondensation of 2‐carbethoxy‐3‐amino‐4‐phenyl‐6‐substituted‐thieno[2,3‐ b ]pyridines (3) with various isothiocyanates. Compounds 5 were S ‐methylated routinely and the reactions compared under solid‐liquid phase transfer conditions to obtain 2‐methylthiopyrido[3′,2′:4,5]thieno[3,2‐ d ]pyrimidin‐4(3 H )‐ ones (6). The new triheterocyclic pyridothienopyrimidines were prepared with the objective to study their pharmacological properties.