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Synthesis of chirally pure 2,5‐disubstituted diketopiperazines derived from trisubstituted phenylalanines
Author(s) -
Danthi Satyavijayan Narasimhan,
Hill Ronald A.
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340321
Subject(s) - diketopiperazines , chemistry , dipeptide , nitration , alcohol , organic chemistry , combinatorial chemistry , amino acid , biochemistry
Some new chirally pure 2,5‐substituted diketopiperazines were synthesized starting from 2‐methoxybenzyl alcohol. This multistep synthesis proceeds through the enzymatic synthesis of chirally pure amino acids, protection and dipeptide coupling, cyclization of dipeptide ester formates, and nitration of the resulting diketopiperazines.