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Synthesis of some piperazinylpyrazolo[3,4‐ b ]pyridines as selective serotonin re‐uptake inhibitors
Author(s) -
Shutske Gregory M.,
Roehr Joachim E.
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340314
Subject(s) - chemistry , serotonin , stereochemistry , intermolecular force , combinatorial chemistry , organic chemistry , biochemistry , molecule , receptor
A number of 3‐substituted 6‐piperazinylpyrazolo[3,4‐ b ]pyridines were synthesized from 2,6‐difluoropyridine by directed ortho metallation and sequential intra‐ and intermolecular displacement of fluorine. Three derivatives with a cyano group in the 3‐position showed activity as selective serotonin re‐uptake inhibitors.