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Synthesis, structure and reactivity of imidazo[1,2‐ a ][1,8]naphthyridines
Author(s) -
Gueiffier Alain,
Viols Henri,
Blache Yves,
Chapat Jean Pierre,
Chavig Olivier,
Teulade Jean Claude,
Fauvelle Florence,
Grassy Gérard,
Dauphin Gérard
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340311
Subject(s) - chemistry , cndo/2 , reactivity (psychology) , electrophilic substitution , electrophile , computational chemistry , substitution reaction , stereochemistry , medicinal chemistry , organic chemistry , catalysis , molecule , pathology , medicine , alternative medicine
The synthesis and reactivity of imidazo[1,2‐ a ][1,8]naphthyridines are reported. Electrophilic substitution reactions were studied and the site of the reaction was established with the aid of high‐field 1 H and 13 C nmr spectra. The experimental C‐1 position reaction was correlated with a CNDO/2 calculations.