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A cyclopropenone route to new pyrrolizidine derivatives
Author(s) -
Kascheres Albert,
Schumacher Heloisa C.,
Rodrigues Reinaldo A. F.
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340309
Subject(s) - chemistry , pyrrolizidine , aldol condensation , yield (engineering) , intramolecular force , aldol reaction , organic chemistry , dehydration , condensation , acetone , stereochemistry , catalysis , biochemistry , materials science , physics , metallurgy , thermodynamics
New pyrrolizidine derivatives 6 and 7 were prepared from the 1, 5‐dihydro‐2 H ‐pyrrol‐2‐one 3a via an acidic intramolecular aldol condensation in 16% and 42% yields, respectively. Compound 6 was obtained by dehydration of 7 with p ‐toluenessulfonic acid in 67% yield.
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