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A new and facile synthesis of imidazo[2,1‐ b ]oxazoles
Author(s) -
Mekonnen Belew,
Crank George,
Craig Donald
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340241
Subject(s) - chemistry , chloride , combinatorial chemistry , titanium , stereochemistry , medicinal chemistry , organic chemistry
An efficient and clean two step procedure for the synthesis of imidazo[2,1‐ b ]oxazoles has been developed from 2‐aminooxazoles using titanium(IV) chloride assisted cyclization, and a variety of imidazo[2,1‐ b ]oxazoles have been synthesized in good yields. The structure of one of the products was confirmed by X‐ray crystallographic analysis.