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A novel synthesis of 3‐halo‐2‐phenylquinoline‐4‐carboxylic acids
Author(s) -
Raveglia Luca F.,
Giardina Giuseppe A. M.,
Grugni Mario,
Rigolio Roberto,
Farina Carlo
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340235
Subject(s) - chemistry , bromine , chlorine , organic chemistry , amino acid , chlorine atom , medicinal chemistry , biochemistry
The 3‐chloro and 3‐bromo‐2‐phenylquinoline‐4‐carboxylic acids were obtained in good yields through a novel procedure, entailing the synthesis of the 3‐amino intermediate and the subsequent replacement of the amino group with chlorine or bromine, according to the Sandmeyer reaction.