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Synthesis and metalation of trifluoromethylpyrimidines. Metalation of diazines. XVI
Author(s) -
Plé N.,
Turck A.,
Heynderickx A.,
Quéguiner G.
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340234
Subject(s) - metalation , chemistry , pyrimidine , combinatorial chemistry , stereochemistry
A new route to trifluoromethylpyrimidines is described. Lithiation of trifluoromethylpyrimidines was successfully achieved and was used to synthesize new pyrimidine derivatives. A new synthetic route to a biologically active molecule with antimycotic activities is reported.