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Synthesis of 6,7‐dihydrobenzo[4,5]cyclohept‐[1,2‐ b ]indol‐12(5 H )‐one and related compounds
Author(s) -
Joseph B.,
Cornec O.,
Mérour J.Y.,
Solans X.,
FontBardia M.
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340229
Subject(s) - chemistry , ketone , indole test , stereochemistry , methyl ketone , carboxylate , bicyclic molecule , medicinal chemistry , organic chemistry
The synthetic routes of 6,7‐dihydrobenzo[4,5]cyclohept[1,2‐ b ]indol‐12(5 H )‐one 5 from either 1‐methyl or 1‐sulfonylindole‐2‐carboxaldehyde 1 or ethyl 1,2‐dimethylindole‐3‐carboxylate 6 are reported. The structure of the ketone 5a was confirmed by X‐ray crystallography. Several indole derivatives have been prepared with potential antitumor activity.