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Synthesis of pyrido[2,3‐ d ]pyrimidinones by the reaction of aminopyrimidin‐4‐ones with benzylidene meldrum's acid derivatives
Author(s) -
Quiroga Jairo,
Hormaza Angelina,
Insuasty Braulio,
Nogueras Manuel,
Sánchez Adolfo,
Hanold Norbert,
Meier Herbert
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340228
Subject(s) - chemistry , pyrimidinones , meldrum's acid , nitrobenzene , boiling , pyrimidine , aniline , stereochemistry , organic chemistry , medicinal chemistry , catalysis
A series of pyrido[2,3‐ d ]pyrimidine‐4,7‐diones 5a‐h were prepared from 6‐amino‐4‐pyrimidones 1 and benzylidene Meldrum's acid derivatives 2 by cyclization reactions in boiling nitrobenzene. The structure of 5, determined by nmr measurements, reveals a selective orientation of 1 and 2 in the addition step.