Synthesis of pyrido[2,3‐ d ]pyrimidinones by the reaction of aminopyrimidin‐4‐ones with benzylidene meldrum's acid derivatives | Zendy

Quiroga Jairo | Zendy; Hormaza Angelina | Zendy; Insuasty Braulio | Zendy; Nogueras Manuel | Zendy; Sánchez Adolfo | Zendy; Hanold Norbert | Zendy; Meier Herbert | Zendy

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Synthesis of pyrido[2,3‐ d ]pyrimidinones by the reaction of aminopyrimidin‐4‐ones with benzylidene meldrum's acid derivatives

Author(s) -

Quiroga Jairo,

Hormaza Angelina,

Insuasty Braulio,

Nogueras Manuel,

Sánchez Adolfo,

Hanold Norbert,

Meier Herbert

Publication year - 1997

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570340228

Subject(s) - chemistry , pyrimidinones , meldrum's acid , nitrobenzene , boiling , pyrimidine , aniline , stereochemistry , organic chemistry , medicinal chemistry , catalysis

A series of pyrido[2,3‐ d ]pyrimidine‐4,7‐diones 5a‐h were prepared from 6‐amino‐4‐pyrimidones 1 and benzylidene Meldrum's acid derivatives 2 by cyclization reactions in boiling nitrobenzene. The structure of 5, determined by nmr measurements, reveals a selective orientation of 1 and 2 in the addition step.

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