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Haloacetylated enol ethers. 8 [12]. Reaction of β‐alkoxyvinyl trihalomethyl ketones with guanidine hydrochloride. Synthesis of 4‐trihalomethyl‐2‐aminopyrimidines
Author(s) -
Zanatta Nilo,
Cortelini Maria de F. M.,
Carpes Marcos J. S.,
Bonacorso Helio G.,
Martins Marcos A. P.
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340226
Subject(s) - chemistry , guanidine , hydrochloride , enol , ketone , organic chemistry , acetal , medicinal chemistry , catalysis
Abstract In this work the results of the reaction of β‐alkoxyvinyl trihalomethyl ketones 1, 2a‐e , with guanidine hydrochloride are reported. Depending on the ketone 1 or 2 and the conditions under which the reactions were carried out, 4‐trihalomethyl‐2‐amino pyrimidines, β‐alkoxyvinyl carboxylic acids, or β‐acetal carboxylic esters were obtained.

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