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Convenient synthesis of 6‐substituted‐2‐chloro‐5,12‐dihydro‐5‐oxobenzoxazolo[3,2‐ a ]quinolines and N ‐acylated‐3‐chlorodibenz[ b,e ][1,4]oxazepin‐11(5 H )‐ones
Author(s) -
Chung Sang J.,
Joo Keum Chan,
Kim Dong H.
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340221
Subject(s) - chemistry , acetic anhydride , yield (engineering) , acylation , anthranilic acid , sodium salt , salt (chemistry) , medicinal chemistry , organic chemistry , sodium , catalysis , inorganic chemistry , materials science , metallurgy
Convenient synthesis of variously substituted 2‐chloro‐5,12‐dihydro‐5‐oxobenzoxazolo[3,2‐ a ]quinolines at the 6‐position and N ‐acylated‐3‐chlorodibenz[ b,e ][1,4]oxazepin‐11(5 H )‐ones are reported. The former compounds were obtained in 65–93% yield by simply heating N ‐acyl‐4‐chloro‐ N ‐(2‐hydroxyphenyl)‐anthranilic acids in acetic anhydride for 4 hours, and the latter by heating sodium salt of N ‐acyl‐4‐chloro‐ N ‐(2‐hydroxyphenyl)anthranilic acids with acetic anhydride.