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A new and efficient route to amino derivatives of [1,6]‐ and [2,7]naphthyridones
Author(s) -
Nemazany Alexei,
Haider Norbert
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340207
Subject(s) - chemistry , base (topology) , amino acid , combinatorial chemistry , organic chemistry , medicinal chemistry , mathematics , mathematical analysis , biochemistry
Reaction of N ‐substituted amides of 2‐chloro‐ or 4‐chloronicotinic acid with CH‐acidic nitriles in the presence of a base provides a convenient access to amino derivatives of 1,6‐naphthyrid‐5(6 H )‐one, compounds of type 4 and 5 , or 2,7‐naphthyrid‐1(2 H )‐one 7.
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