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Studies on pyrrolidinones. Synthesis of some bioisosteres of 3,3,5‐trimethylcyclohexyl pyroglutamate
Author(s) -
Rigo Benoǐt,
Laruelle Claude
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340142
Subject(s) - pyrrolidinones , chemistry , pyroglutamic acid , stereochemistry , biochemistry , amino acid
The synthesis of new N ‐(4‐chlorobenzyl) and N ‐(4‐chlorobenzoyl)pyroglutamic esters and amids whose the structure conserves the main structural features of the cholesterol lowering agent crilvastatin is described.