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Intramolecular cyclization of amido acids into pyrrolidinothieno(or [1]benzothieno)[3]azepinediones
Author(s) -
Othman Mohamed,
Netchitailo Pierre,
Decroix Bernard
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340134
Subject(s) - chemistry , triethylsilane , intramolecular force , acetic acid , stereochemistry , medicinal chemistry , organic chemistry , catalysis
The synthesis of pyrrolidino[2,1‐ b ]thieno[3,2(2,3)‐ f ][3]azepinediones 7a,b and pyrrolidino[2,1‐ b ]‐[1]benzothieno[3,2(2,3)‐ f ][3]azepinediones 7c,d are described starting from thiophenes or [1]benzothio‐phenes acetic acids. Their selective reduction using triethylsilane led to the corresponding azepinones 17a‐d.