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Synthesis of 2‐substituted 4‐quinazolone‐5‐carboxylic acids as inhibitors of DNA‐gyrase
Author(s) -
Sui Zhihua,
Nguyen Van N.,
Fernandez Jeff,
Barrett John F.,
Ohemeng Kwasi A.
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340124
Subject(s) - dna gyrase , chemistry , dna , stereochemistry , carboxylic acid , inhibitory postsynaptic potential , biochemistry , combinatorial chemistry , escherichia coli , gene , medicine
A series of 4‐quinazolone‐5‐carboxylic acids were designed as bacterial DNA gyrase inhibitors. The syntheses of the target compounds were accomplished by reacting 3‐aminophthalimide with aroyl chlorides followed by rearrangement of the resulting 3‐acylaminophthalimides under basic conditions. The designed compounds showed moderate DNA gyrase inhibitory activity.