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Synthesis of imidazo[4,5‐ b ]pyridines from aminoimidazolecarbaldehydes
Author(s) -
Perandones Francisco,
Soto Jose L.
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340118
Subject(s) - chemistry , moiety , pyridine , condensation , medicinal chemistry , organic chemistry , stereochemistry , physics , thermodynamics
4‐Amino‐1,2‐dimethylimidazole‐5‐carbaldehyde (1) and 5‐amino‐1‐methylimidazole‐4‐carbaldehydes 3 were prepared by reduction of the corresponding aminoimidazolecarbonitriles 2 and 4. Condensation of 1 and 3 with carbonitriles, ketones and polyfunctional carbonyl compounds bearing the‐CH 2 CO‐moiety afforded to the imidazo[4,5‐ b ]pyridine derivatives.