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Synthesis of novel pyridazino[3,4‐ b ]quinoxalines
Author(s) -
Kim Ho Sik,
Kim Eun Kyoung,
Kim Sung Sik,
Park Yong Tae,
Hong Young Seuk,
Kurasawa Yoshihisa
Publication year - 1997
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570340107
Subject(s) - chemistry , quinoxaline , hydrazide , sodium azide , phosphoryl chloride , azide , medicinal chemistry , chloride , combinatorial chemistry , stereochemistry , organic chemistry
The pyridazino[3,4‐ b ]quinoxaline 12 was synthesized by the cyclization of the α‐arylhydrazonoacyl‐hydrazide 11. The reaction of compound 12 with phosphoryl chloride gave pyridazino[3,4‐ b ]quinoxaline 13, whose reactions with sodium azide or cyclic secondary amines provided pyridazino[3,4‐ b ]quinoxalines 14,17 and 18, respectively. The acylhydrazide 15 was also cyclized to pyridazino[3,4‐ b ]quinoxaline 16.
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