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Synthesis of a 9‐acridinyl nonapeptide containing the DNA recognizing region of 434 phage repressor protein
Author(s) -
Takenaka Shigeori,
Iwamasa Kenji,
Takagi Makoto,
Nishino Norikazu,
Mihara Hisakazu,
Fujimoto Tutomu
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330678
Subject(s) - chemistry , repressor , conjugate , dna , acridine , peptide , sequence (biology) , microbiology and biotechnology , stereochemistry , biochemistry , gene , biology , organic chemistry , mathematical analysis , mathematics , transcription factor
A peptide‐intercalator conjugate was synthesized by connecting acridine with a Gln‐Gln‐Ser‐Ile‐Glu‐Gln‐Leu‐Glu‐Asn sequence representing the DNA recognizing region of 434 phage repressor protein. This conjugate 7 binds to DNA in spite of its anionic character with the aid of the intercalator.