Synthesis of 9‐[(2‐hydroxy‐1‐phosphonylethoxy)ethyl]guanine, 1‐[(2‐hydroxy‐1‐phosphonylethoxy)ethyl]cytosine and 9‐[(2‐hydroxy‐1‐phosphonylethoxy)ethyl] adenine | Zendy

Kim DaeKee | Zendy; Gam Jongsik | Zendy; Kim Key H. | Zendy

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Synthesis of 9‐[(2‐hydroxy‐1‐phosphonylethoxy)ethyl]guanine, 1‐[(2‐hydroxy‐1‐phosphonylethoxy)ethyl]cytosine and 9‐[(2‐hydroxy‐1‐phosphonylethoxy)ethyl] adenine

Author(s) -

Kim DaeKee,

Gam Jongsik,

Kim Key H.

Publication year - 1996

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570330651

Subject(s) - chemistry , cytosine , phosphonate , guanine , pyrimidine , stereochemistry , purine , nucleoside , nucleotide , dna , organic chemistry , biochemistry , enzyme , gene

The acyclic nucleoside phosphonate analogues, 9‐[(2‐hydroxy‐1‐phosphonylethoxy)ethyl]guanine 6 , 1‐[(2‐hydroxy‐1‐phosphonylethoxy)ethyl]cytosine 7 and 9‐[(2‐hydroxy‐1‐phosphonylethoxy)ethyl]adenine 8 , have been prepared by the coupling of a tosylate of the phosphonate side chain 12 with a purine or pyrimidine base followed by deprotection of the blocking groups.

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