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Synthesis of 9‐[(2‐hydroxy‐1‐phosphonylethoxy)ethyl]guanine, 1‐[(2‐hydroxy‐1‐phosphonylethoxy)ethyl]cytosine and 9‐[(2‐hydroxy‐1‐phosphonylethoxy)ethyl] adenine
Author(s) -
Kim DaeKee,
Gam Jongsik,
Kim Key H.
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330651
Subject(s) - chemistry , cytosine , phosphonate , guanine , pyrimidine , stereochemistry , purine , nucleoside , nucleotide , dna , organic chemistry , biochemistry , enzyme , gene
The acyclic nucleoside phosphonate analogues, 9‐[(2‐hydroxy‐1‐phosphonylethoxy)ethyl]guanine 6 , 1‐[(2‐hydroxy‐1‐phosphonylethoxy)ethyl]cytosine 7 and 9‐[(2‐hydroxy‐1‐phosphonylethoxy)ethyl]adenine 8 , have been prepared by the coupling of a tosylate of the phosphonate side chain 12 with a purine or pyrimidine base followed by deprotection of the blocking groups.