Synthesis and evaluation of 1 H ‐pyrazolo[3,4‐ b ]quinoxalines and 1‐aryl‐3‐quinoxalinyl‐1,2,4‐triazole as antibacterial agent | Zendy

Kim Ho Sik | Zendy; Chung Ju Young | Zendy; Kim Eun Kyoung | Zendy; Park Yong Tae | Zendy; Hong Young Seuk | Zendy; Lee Man Kil | Zendy; Kurasawa Yoshihisa | Zendy; Takada Atsushi | Zendy

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Synthesis and evaluation of 1 H ‐pyrazolo[3,4‐ b ]quinoxalines and 1‐aryl‐3‐quinoxalinyl‐1,2,4‐triazole as antibacterial agent

Author(s) -

Kim Ho Sik,

Chung Ju Young,

Kim Eun Kyoung,

Park Yong Tae,

Hong Young Seuk,

Lee Man Kil,

Kurasawa Yoshihisa,

Takada Atsushi

Publication year - 1996

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570330649

Subject(s) - chemistry , aryl , bacillus licheniformis , triazole , antibacterial activity , 1,2,4 triazole , combinatorial chemistry , stereochemistry , bacillus subtilis , organic chemistry , bacteria , alkyl , biology , genetics

Novel 1 H ‐pyrazolo[3,4‐ b ]quinoxalines (flavazoles) 14, 15 and 1‐aryl‐3‐quinoxalinyl‐1,2,4‐triazole 17 were synthesized from the ester 11 via various hydrazones 12, 13 and 16 . In the antibacterial screening test of compounds 12–17 , compound 14 showed a relatively high antibacterial activity, wherein the MIC value was 25 μg/ml against Bacillus licheniformis KTCC 21425 and Cellulomonas sp. and 50 μg/ml against Salmonella typhimurium KCTC 1925 and Flavobacterium devolans .

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