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A convenient synthesis of 4‐amino‐3,5‐dialkyl‐4 H ‐1,2,4‐triazoles
Author(s) -
Lkizler Aysun,
Demirbas Neslihan,
Lkizler Aykut A.
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330636
Subject(s) - chemistry , combinatorial chemistry , stereochemistry , medicinal chemistry
Ester tert ‐butoxycarbonylhydrazones 2 were reacted with some carboxylic acid hydrazides to give 4 ‐terrtutoxycarbonylamino‐3,5‐dialkyl‐4 H ‐1,2,4‐triazoles 3–6 . Treatment of 3–5 with 6 N hydrochloric acid under mild conditions resulted in the formation of 4‐ammo‐3,5‐dialkyl‐4 H ‐1,2,4‐triazole hydrochlorides 7–9 in good yields. Compound 7a was converted to the free 4 ‐amino compound 10a upon treatment with ethanolic sodium ethoxide solution.