A convenient synthesis of 4‐amino‐3,5‐dialkyl‐4 H ‐1,2,4‐triazoles | Zendy

Lkizler Aysun | Zendy; Demirbas Neslihan | Zendy; Lkizler Aykut A. | Zendy

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A convenient synthesis of 4‐amino‐3,5‐dialkyl‐4 H ‐1,2,4‐triazoles

Author(s) -

Lkizler Aysun,

Demirbas Neslihan,

Lkizler Aykut A.

Publication year - 1996

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570330636

Subject(s) - chemistry , combinatorial chemistry , stereochemistry , medicinal chemistry

Ester tert ‐butoxycarbonylhydrazones 2 were reacted with some carboxylic acid hydrazides to give 4 ‐terrtutoxycarbonylamino‐3,5‐dialkyl‐4 H ‐1,2,4‐triazoles 3–6 . Treatment of 3–5 with 6 N hydrochloric acid under mild conditions resulted in the formation of 4‐ammo‐3,5‐dialkyl‐4 H ‐1,2,4‐triazole hydrochlorides 7–9 in good yields. Compound 7a was converted to the free 4 ‐amino compound 10a upon treatment with ethanolic sodium ethoxide solution.

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