Pyridazines  LXXVIII    On the reactivity of 4‐methoxy‐[(4‐pyridazinyl)methylidene]aniline in ester enolate‐imine condensation reactions | Zendy

Heinisch Gottfried | Zendy; Langer Thierry | Zendy; Tonnel Jacques | Zendy

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Pyridazines LXXVIII On the reactivity of 4‐methoxy‐[(4‐pyridazinyl)methylidene]aniline in ester enolate‐imine condensation reactions

Author(s) -

Heinisch Gottfried,

Langer Thierry,

Tonnel Jacques

Publication year - 1996

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570330631

Subject(s) - chemistry , pyridazine , carbanion , aldimine , imine , nucleophile , aniline , reactivity (psychology) , condensation , lithium (medication) , medicinal chemistry , ring (chemistry) , nucleophilic addition , condensation reaction , organic chemistry , catalysis , medicine , physics , alternative medicine , pathology , thermodynamics , endocrinology

Reactions of the pyridazine derived aldimine 1 with lithium enolates of various α‐substituted acetates were investigated. An unprecedented formation of the pyrido[3,4‐ d ]pyridazine system due to nucleophilic attack of a carbanion species at the β‐position of the pyridazine ring was observed.

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