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Pyridazines LXXVIII On the reactivity of 4‐methoxy‐[(4‐pyridazinyl)methylidene]aniline in ester enolate‐imine condensation reactions
Author(s) -
Heinisch Gottfried,
Langer Thierry,
Tonnel Jacques
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330631
Subject(s) - chemistry , pyridazine , carbanion , aldimine , imine , nucleophile , aniline , reactivity (psychology) , condensation , lithium (medication) , medicinal chemistry , ring (chemistry) , nucleophilic addition , condensation reaction , organic chemistry , catalysis , medicine , physics , alternative medicine , pathology , thermodynamics , endocrinology
Reactions of the pyridazine derived aldimine 1 with lithium enolates of various α‐substituted acetates were investigated. An unprecedented formation of the pyrido[3,4‐ d ]pyridazine system due to nucleophilic attack of a carbanion species at the β‐position of the pyridazine ring was observed.