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Cyclization of 2‐ and 3‐indolythioalkanoic acids to novel indole‐containing tricyclic ring systems
Author(s) -
Hamel Pierre,
Girard Mario
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330624
Subject(s) - indole test , chemistry , ring (chemistry) , tricyclic , stereochemistry , organic chemistry
A series of 2‐ and 3‐indolylthioalkanoic acids of various chain lengths were cyclized under dehydrative conditions affording tricyclic indole‐containing ring systems wherein the third ring contains a sulfur atom attached to the 2‐ or 3‐position of the indole ring. This methodology affords entry into the novel thiepino[3,2‐ b ]indole, thiocino[2,3 ‐b ]indole and thiocino[3,2‐ b ]indole ring systems.