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Polycyclic N ‐heterocyclic compounds. 51 . Synthesis of novel 12‐substituted 11,13,15‐triazasteroidal compounds and their inhibitory activity on platelet aggregation
Author(s) -
Sasaki Kenji,
Arichi Takeshi,
Ohtomo Hiromi,
Nakayama Taiji,
Hirota Takashi
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330619
Subject(s) - chemistry , inhibitory postsynaptic potential , platelet aggregation , stereochemistry , platelet , neuroscience , immunology , biology
Synthesis of 11‐substituted 1,2,4,5‐tetrahydrobenzo[ h ]imidazo[1,2‐ c ]quinazolines corresponding to 12‐substituted 11,13,15‐triazasteroid is described. Evaluation on inhibitory activity against collagen‐induced platelet aggregation of these compounds and their precursors was also investigated.