Regioselective synthesis of 9‐substituted‐8‐azaguanines (5‐amino‐3‐substituted‐3,6‐dihydro‐7 H ‐1,2,3‐triazolo[4,5‐ d ]pyrimidin‐7‐one) | Zendy

Sznaidman Marcos L. | Zendy; Beauchamp Lilia M. | Zendy

Premium

Regioselective synthesis of 9‐substituted‐8‐azaguanines (5‐amino‐3‐substituted‐3,6‐dihydro‐7 H ‐1,2,3‐triazolo[4,5‐ d ]pyrimidin‐7‐one)

Author(s) -

Sznaidman Marcos L.,

Beauchamp Lilia M.

Publication year - 1996

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570330609

Subject(s) - regioselectivity , chemistry , stereochemistry , combinatorial chemistry , organic chemistry , catalysis

By modifying previously described methods for the synthesis of 9‐substituted‐guanines from imidazoles, we have developed a new procedure for the regioselective synthesis of 9‐substituted‐8‐azaguanines (5‐amino‐3‐substituted‐3,6‐dihydro‐7 H ‐1,2,3‐triazolo[4,5‐ d ]pyrimidin‐7‐one) from triazoles in high yields. The method seems suitable for the introduction of a variety of substituents including sugars, carbocyclic, acyclic and carboacyclic chains.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research