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Regioselective synthesis of 9‐substituted‐8‐azaguanines (5‐amino‐3‐substituted‐3,6‐dihydro‐7 H ‐1,2,3‐triazolo[4,5‐ d ]pyrimidin‐7‐one)
Author(s) -
Sznaidman Marcos L.,
Beauchamp Lilia M.
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330609
Subject(s) - regioselectivity , chemistry , stereochemistry , combinatorial chemistry , organic chemistry , catalysis
By modifying previously described methods for the synthesis of 9‐substituted‐guanines from imidazoles, we have developed a new procedure for the regioselective synthesis of 9‐substituted‐8‐azaguanines (5‐amino‐3‐substituted‐3,6‐dihydro‐7 H ‐1,2,3‐triazolo[4,5‐ d ]pyrimidin‐7‐one) from triazoles in high yields. The method seems suitable for the introduction of a variety of substituents including sugars, carbocyclic, acyclic and carboacyclic chains.