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The synthesis of 3‐bromo‐2,4,5‐trifluorobenzoic acid and its conversion to 8‐bromoquinolonecarboxylic acids
Author(s) -
Renau Thomas E.,
Sanchez Joseph R.,
Domagala John M.
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330466
Subject(s) - chemistry , oxazoline , boron , organic chemistry , combinatorial chemistry , catalysis
Abstract A series of 8‐bromo‐4‐oxo‐3‐quinolinecarboxylic acids was prepared via the borate ester, 8 . The key intermediate in the synthesis of the final products 10a‐10d was 3‐bromo‐2,4,5‐trifluorobenzoic acid ( 3 ), conveniently prepared in two steps from the known oxazoline, 1 . The preparation of 10a‐10d is a significant improvement of the literature procedure currently available for the synthesis of these compounds.