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Synthesis and reactivity of oxopyrrolidinothieno[2]azepinones: [3]Benzazepine antidepressant analogs
Author(s) -
Mamouni AÏCha,
Daïch Adam,
Decroix Bernard
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330443
Subject(s) - chemistry , benzazepine , succinimide , stereoselectivity , stereochemistry , beckmann rearrangement , reactivity (psychology) , ring (chemistry) , thiophene , organic chemistry , medicinal chemistry , oxime , catalysis , medicine , alternative medicine , pathology
A synthesis of oxopyrrolidino[2]azepinones annelated to a thiophene ring 3a,b,c is described starting from succinimide and halogenomethylthiophenes 6a,b,c . Stereoselective reduction, Schmidt reaction and the Beckmann rearrangement of the oximes of the ketones 3a,b,c are studied.
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