Premium
Reactivity of α‐acylated β‐enamino ketones and esters: Synthesis of pyrazoles
Author(s) -
Missio Lauri J.,
Braibante Hugo S.,
Braibante Mara E. F.
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330441
Subject(s) - chemistry , hydrazine (antidepressant) , thio , reactivity (psychology) , hydrate , pyrazole , electrophile , hydrochloride , medicinal chemistry , organic chemistry , catalysis , medicine , alternative medicine , pathology , chromatography
The reactivity of the enamino compounds 4‐amino‐3‐phenylamino(thio)carbonyl‐3‐penten‐2‐one 1 and 2 and ethyl 3‐amino‐2‐phenylamino(thio)carbonyl‐2‐butyrate 7 and 8 was studied using the reaction with hydrazine hydrate and hydrazine hydrochloride to evaluate the 1,3 electrophilic center of the compounds by the formation of the pyrazole rings. The pyrazoles 3, 4, 5, 9, 11 and 13 were obtained depending on the reaction conditions employed.