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Aroylation of 5‐amino‐2 H ‐1,2,4‐thiadiazolin‐3‐ones
Author(s) -
Cho Nam Sook,
Ra Chan Soo,
Ra Do Young,
Song Jin Soo,
Kang Sung Kwon
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330433
Subject(s) - chemistry , ab initio , pyridine , computational chemistry , molecular orbital , chloride , stereochemistry , medicinal chemistry , molecule , organic chemistry
Abstract 2‐Aroyl‐5‐aroylamino‐1,2,4‐thiadiazolin‐3‐ones ( 2 ) have been synthesized through aroylation of 5‐arruno‐2 H ‐1,2,4‐thiadiazolin‐3‐one ( 1 ) as an analog of cytosine. The aroylation was carried out with a substituted aroyl chloride in pyridine at 56∼58°C. It has been established that the intermediates of the reactions are 2‐aroyl‐5‐amino‐1,2,4‐thiadiazolin‐3‐ones ( 3 ) on the basis of the spectral data, additional experimental information and ab initio molecular orbital calculations.