Premium
Alkylation and arylation at the C‐3′ side chain position of cephalosporins via a pummerer intermediate
Author(s) -
Gourdoupis Christos G.,
Stamos Ioannis K.
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330371
Subject(s) - chemistry , pummerer rearrangement , trifluoroacetic anhydride , nucleophile , side chain , trifluoroacetic acid , lactam , cephalosporin , alkylation , lewis acids and bases , organic chemistry , stereochemistry , catalysis , acetic anhydride , biochemistry , antibiotics , polymer
The Pummerer intermediate generated from a 3‐exomethylene‐1‐oxocephem with trifluoroacetic anhydride was trapped intermolecularly in the presence of a Lewis acid by some aromatic or olefinic nucleophiles.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom