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Synthesis of 2‐(ω‐aminoalkyl)imidazolin‐4‐ones by ring chain transformation of lactam derivatives with α‐aminoamides
Author(s) -
Rottmann Antje,
Liebscher Jürgen
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330345
Subject(s) - chemistry , lactam , ring (chemistry) , condensation , transformation (genetics) , stereochemistry , chain (unit) , organic chemistry , biochemistry , physics , astronomy , gene , thermodynamics
Reaction of N ‐methylamides of biogenic ( S )‐α‐amino acids 3 with lactam acetals 1 or lactim ethers 2 gives three types of products, i.e. N ‐methyl‐α‐lactamiminoamides 5 by condensation, 2‐(ω‐aminoalkyl)imidazolin‐5‐ones 7 or 2‐(ω‐lactamimmoalkyl)imidazolin‐4‐ones 8 by ring chain transformation. All products represent novel optically active derivatives of biogenic α‐aminoacids.