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Heteroannulation of naphthoquinones. Studies on the reaction of 2‐bromo‐2,3‐dihydronaphthoquinone derivatives with 1,2‐binucleophiles.
Author(s) -
Couladouros Elias A.,
Plyta Zoi F.,
Iliadis Theodoros,
Roussis Vassilios,
Papageorgiou Vassilios P.
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330331
Subject(s) - chemistry , stereochemistry , combinatorial chemistry , organic chemistry , medicinal chemistry
Heterocyclic derivatives of naphthoquinones were synthesized via their 2‐bromo‐2,3‐dehydro‐intermediates. This new route may lead to the formation of benzo[ a ]phenothiazin‐5‐ones, benzo[ f ]quinoxalin‐6‐ones as well as their 1,4 (or 7,10) dihydroxy‐derivatives in high yields. The possible mechanisms involved in the formation of these compounds are discussed.
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